TY - JOUR
T1 - Role of calcium ions in the stimulatory actions of luteinizing hormone in isolated ovarian cells
T2 - Studies with divalent-cation ionophores
AU - Veldhuis, Johannes D.
AU - Klase, Patricia A.
N1 - Funding Information:
LH was generously supplied by the Hormone Distribution Office of NIAMDD. We thank the Shamokin Packing Corp. and Arbogast and Bastian for porcine ovaries, and Xarlene Thompson and Judy Woodson for the preparation of this manuscript. This work was supported by a National Research Service Award (LF32HD05755) to J.D. Veldhuis from NICHD.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1982/1/29
Y1 - 1982/1/29
N2 - The divalent-cation ionophores A23187 and ionomycin exert dose-dependent suppressive effects on the stimulatory actions of luteinizing hormone in ovarian cells invitro. Micromolar concentrations of both A23187 and ionomycin can inhibit the production of progesterone and the stimulation of ornithine decarboxylase activity. Inhibitory concentrations of these ionophores deplete total cell content of calcium, and also seem to suppress protein synthesis.
AB - The divalent-cation ionophores A23187 and ionomycin exert dose-dependent suppressive effects on the stimulatory actions of luteinizing hormone in ovarian cells invitro. Micromolar concentrations of both A23187 and ionomycin can inhibit the production of progesterone and the stimulation of ornithine decarboxylase activity. Inhibitory concentrations of these ionophores deplete total cell content of calcium, and also seem to suppress protein synthesis.
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U2 - 10.1016/0006-291X(82)90680-5
DO - 10.1016/0006-291X(82)90680-5
M3 - Article
C2 - 6803785
AN - SCOPUS:0020083352
SN - 0006-291X
VL - 104
SP - 603
EP - 610
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -