Risk factors that mitigate the role of paraaortic lymphadenectomy in uterine endometrioid cancer

S. Kumar, A. Mariani, J. N. Bakkum-Gamez, A. L. Weaver, M. E. McGree, G. L. Keeney, W. A. Cliby, K. C. Podratz, S. C. Dowdy

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Objective Paraaortic lymph node (PA) dissemination in endometrial cancer (EC) is uncommon and a systematic infrarenal PA dissection carries morbidity. Our objective was to identify a subgroup of EC patients who may potentially forego PA lymphadenectomy (LND). Methods The study endpoint (PA Metastasis or Recurrence; PAMR) was defined as detection of metastasis to PA nodes (among those with any type of PA LND) or PA recurrence within 2 years (among patients without PA LND or those with negative nodes in the context of an inadequate (< 5 nodes) PA LND). Patients with non-endometrioid histology, stage IV disease, synchronous cancers, gross extrauterine or gross adnexal disease, neoadjuvant therapy, or insufficient follow-up were excluded. Multivariable logistic regression analysis identified predictors of PAMR. Results Of the 946 patients, PAMR was observed in 4% (36/946). Multivariable analysis identified positive pelvic nodes (odds ratio (OR) 24.2; p < 0.001), > 50% MI (OR 5.3; p < 0.001) and lymphovascular space invasion (LVSI) (OR 3.7; p = 0.005) as the only three independent predictors of PAMR. When all three factors were absent (77% of study cohort), the predicted probability of PAMR was 0.6%. If intraoperative frozen section is not available on pelvic lymph nodes and LVSI, omitting PA LND in all patients with ≤ 50% MI would affect 84% (792/946) of the total cohort, with a 1.1% risk of PAMR (9/792). Conclusion The majority of patients with endometrioid EC may potentially forgo PA LND with expected reductions in surgical morbidity and cost. This cohort may be identified by a combined absence of: positive pelvic nodes, > 50% MI and LVSI.

Original languageEnglish (US)
Pages (from-to)441-445
Number of pages5
JournalGynecologic oncology
Issue number3
StatePublished - Sep 2013


  • Endometrial cancer
  • Lymphadenectomy
  • Lymphovascular space invasion
  • Myometrial invasion
  • Paraaortic lymph nodes

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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