Risk factors for spinal osteoporosis in men

Ego Seeman, L. Joseph Melton, W. Michael O'Fallon, B. Lawrence Riggs

Research output: Contribution to journalArticlepeer-review

523 Scopus citations


Risk factors for vertebral fractures due to osteoporosis were evaluated in 105 consecutive male patients over a four-year period. An equal number of men with Paget's disease, matched by age, who concurrently attended the same subspecialty clinic served as control subjects. The relative risk for osteoporosis, estimated by the odds ratio, was increased among those who smoke cigarettes (relative risk = 2.3; p = 0.01), drank alcoholic beverages (relative risk = 2.4; p = 0.02), or had an associated medical disease known to affect calcium or bone metabolism (relative risk = 5.5; p < 0.001). Obesity was protective (relative risk = 0.3; p < 0.001). As assessed by a multiple logistic model, the risk associated with smoking and drinking increased with age. The effects of these four major risk factors were largely independent of one another and were cumulative. Thus, spinal osteoporosis in men is frequently associated with recognizable risk factors, some of which are potentially remediable.

Original languageEnglish (US)
Pages (from-to)977-983
Number of pages7
JournalThe American Journal of Medicine
Issue number6
StatePublished - Dec 1983

ASJC Scopus subject areas

  • Medicine(all)


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