Risk factors for breast carcinoma in women with proliferative breast disease

William D. Dupont, Amy C Degnim, Melinda E. Sanders, Jean F. Simpson, Lynn C. Hartmann

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


We review the evidence that proliferative breast disease increases the risk of breast cancer. Results from six cohorts give consistent estimates of these risks. The combined estimate of the relative risk associated with proliferative disease without atypia is 1.65 with a 95% confidence interval (CI) of 1.5 to 1.9. The relative risk of breast cancer associated with atypical hyperplasia is 4.19 (95% CI 3.7-4.7). Estimates of the cumulative absolute risk of invasive breast cancer in the Nashville Breast Cohort and the Mayo Clinic Cohort are also given. These risks are remarkably consistent and average about 25% in the 25 years after a diagnosis of atypical hyperplasia. The chapter also reviews the evidence on how age, a family history of breast cancer, and proliferative breast disease interact to affect breast cancer risk. The risks associated with fibroadenoma and radial scar are also reviewed, as are the effects of time since diagnosis and the risk of hormone replacement therapy in women with a history of proliferative disease.

Original languageEnglish (US)
Title of host publicationThe Breast
Subtitle of host publicationComprehensive Management of Benign and Malignant Diseases
PublisherElsevier Inc.
ISBN (Print)9780323359559
StatePublished - Aug 24 2017


  • Atypical hyperplasia
  • Breast neoplasms pathology/prevention and control
  • Breast pathology
  • Proliferative disease without atypia
  • Risk assessment

ASJC Scopus subject areas

  • Medicine(all)


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