Risk Factor Profiles Can Distinguish Esophageal Adenocarcinoma From Barrett's Esophagus

Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka

Research output: Contribution to journalArticlepeer-review


INTRODUCTION:It is assumed that screening risk factors for Barrett's esophagus (BE) and prevalent esophageal adenocarcinoma (EAC) are the same.METHODS:A matched case-control study comparing risk factors between EAC and BE was performed.RESULTS:In 1,356 patients (678 with EAC and 678 with BE), heartburn (52.7%), diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome were less common in EAC (52.7, 29.2, 45.7, 48.2, 12, and 28.5%, resp.) compared with BE (84.5, 37.6, 82.2, 64.6, 18.4, and 44.1%, P < 0.01). Mean alanine aminotransferase and HgA1c levels were also significantly lower in EAC compared with BE.DISCUSSION:Optimal strategies for screening for prevalent EAC may be different than that for BE.

Original languageEnglish (US)
Pages (from-to)198-201
Number of pages4
JournalAmerican Journal of Gastroenterology
Issue number1
StatePublished - Jan 1 2021

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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