Ribosome display technology: Applications in disease diagnosis and control

Adinarayana Kunamneni, Christian Ogaugwu, Steven Bradfute, Ravi Durvasula

Research output: Contribution to journalReview articlepeer-review


Antibody ribosome display remains one of the most successful in vitro selection technologies for antibodies fifteen years after it was developed. The unique possibility of direct generation of whole proteins, particularly single-chain antibody fragments (scFvs), has facilitated the establishment of this technology as one of the foremost antibody production methods. Ribosome display has become a vital tool for efficient and low-cost production of antibodies for diagnostics due to its advantageous ability to screen large libraries and generate binders of high affinity. The remarkable flexibility of this method enables its applicability to various platforms. This review focuses on the applications of ribosome display technology in biomedical and agricultural fields in the generation of recombinant scFvs for disease diagnostics and control.

Original languageEnglish (US)
Article number28
Pages (from-to)1-17
Number of pages17
Issue number3
StatePublished - Sep 2020


  • Antibodies
  • Diagnostics
  • Disease control
  • Ribosome display

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Drug Discovery


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