Review of Select Sleep Medicine Pharmacology: Treatments of Hypersomnias and Parasomnia

Kimberly Johnson, Meghna P. Mansukhani, Bhanu Prakash Kolla

Research output: Chapter in Book/Report/Conference proceedingChapter


The field of sleep medicine has made several strides forward in the understanding and treatment of various sleep disorders. These discoveries have further highlighted the intricate nature of sleep regulation and the multiple concerted processes required for normal sleep behavior. In this chapter, we will review current pathophysiologic understanding and available treatments for the conditions of hypersomnia and parasomnias. In recent years, advances in the understanding of hypersomnia have been particularly exciting with the discovery of hypocretin/orexin signaling and several newly FDA-approved pharmaceuticals for hypersomnia treatment. Each section concludes with a summary of the available pharmaceuticals, and comprehensive table is provided at the end of the chapter.

Original languageEnglish (US)
Title of host publicationComprehensive Pharmacology
Number of pages21
ISBN (Electronic)9780128204726
StatePublished - Jan 1 2022


  • Disorders of arousal
  • Hypersomnia
  • Idiopathic hypersomnia
  • Kleine-Levin syndrome
  • Medications
  • NREM-related parasomnias
  • Narcolepsy
  • Parasomnias
  • REM sleep behavior disorder
  • REM-related parasomnias

ASJC Scopus subject areas

  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)


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