Review of Multiple Myeloma Genetics including Effects on Prognosis, Response to Treatment, and Diagnostic Workup

Julia Erin Wiedmeier-Nutor; Peter Leif Bergsagel

doi:10.3390/life12060812

Review of Multiple Myeloma Genetics including Effects on Prognosis, Response to Treatment, and Diagnostic Workup

Julia Erin Wiedmeier-Nutor, Peter Leif Bergsagel

Hematology/Oncology

Research output: Contribution to journal › Review article › peer-review

Abstract

Multiple myeloma is a disorder of the monoclonal plasma cells and is the second most common hematologic malignancy. Despite improvements in survival with newer treatment regimens, multiple myeloma remains an incurable disease and most patients experience multiple relapses. Multiple myeloma disease initiation and progression are highly dependent on complex genetic aberrations. This review will summarize the current knowledge of these genetic aberrations, how they affect prognosis and the response to treatment, and review sensitive molecular techniques for multiple myeloma workup, with the ultimate goal of detecting myeloma progression early, allowing for timely treatment initiation.

Original language	English (US)
Article number	812
Journal	Life
Volume	12
Issue number	6
DOIs	https://doi.org/10.3390/life12060812
State	Published - Jun 2022

Keywords

cytogenetics
minimal residual disease
molecular genetics
multiple myeloma
mutation
targetable therapies

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Biochemistry, Genetics and Molecular Biology(all)
Space and Planetary Science
Palaeontology

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10.3390/life12060812

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title = "Review of Multiple Myeloma Genetics including Effects on Prognosis, Response to Treatment, and Diagnostic Workup",

abstract = "Multiple myeloma is a disorder of the monoclonal plasma cells and is the second most common hematologic malignancy. Despite improvements in survival with newer treatment regimens, multiple myeloma remains an incurable disease and most patients experience multiple relapses. Multiple myeloma disease initiation and progression are highly dependent on complex genetic aberrations. This review will summarize the current knowledge of these genetic aberrations, how they affect prognosis and the response to treatment, and review sensitive molecular techniques for multiple myeloma workup, with the ultimate goal of detecting myeloma progression early, allowing for timely treatment initiation.",

keywords = "cytogenetics, minimal residual disease, molecular genetics, multiple myeloma, mutation, targetable therapies",

author = "Wiedmeier-Nutor, {Julia Erin} and Bergsagel, {Peter Leif}",

note = "Funding Information: Funding: This work is funded in part through the Paula and Rodger Riney Foundation. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jun,

doi = "10.3390/life12060812",

language = "English (US)",

volume = "12",

journal = "Life",

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AU - Wiedmeier-Nutor, Julia Erin

AU - Bergsagel, Peter Leif

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Y1 - 2022/6

N2 - Multiple myeloma is a disorder of the monoclonal plasma cells and is the second most common hematologic malignancy. Despite improvements in survival with newer treatment regimens, multiple myeloma remains an incurable disease and most patients experience multiple relapses. Multiple myeloma disease initiation and progression are highly dependent on complex genetic aberrations. This review will summarize the current knowledge of these genetic aberrations, how they affect prognosis and the response to treatment, and review sensitive molecular techniques for multiple myeloma workup, with the ultimate goal of detecting myeloma progression early, allowing for timely treatment initiation.

AB - Multiple myeloma is a disorder of the monoclonal plasma cells and is the second most common hematologic malignancy. Despite improvements in survival with newer treatment regimens, multiple myeloma remains an incurable disease and most patients experience multiple relapses. Multiple myeloma disease initiation and progression are highly dependent on complex genetic aberrations. This review will summarize the current knowledge of these genetic aberrations, how they affect prognosis and the response to treatment, and review sensitive molecular techniques for multiple myeloma workup, with the ultimate goal of detecting myeloma progression early, allowing for timely treatment initiation.

KW - cytogenetics

KW - minimal residual disease

KW - molecular genetics

KW - multiple myeloma

KW - mutation

KW - targetable therapies

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JO - Life

JF - Life

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M1 - 812

ER -

Review of Multiple Myeloma Genetics including Effects on Prognosis, Response to Treatment, and Diagnostic Workup

Abstract

Keywords

ASJC Scopus subject areas

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