Review of Atypical Organometallic Compounds as Antimalarial Drugs

Samuel K. Kwofie; Samuel K. Kwofie; Samuel K. Kwofie; Emmanuel Broni; Bismark Dankwa; Kweku S. Enninful; Joshua Teye; Cedar R. Davidson; Josephine B. Nimely; J. Chioma Orizu; Prakasha Kempaiah; Brijesh Rathi; Brijesh Rathi; Whelton A. Miller; Whelton A. Miller; Whelton A. Miller

doi:10.1155/2020/9414093

Review of Atypical Organometallic Compounds as Antimalarial Drugs

Samuel K. Kwofie, Samuel K. Kwofie, Samuel K. Kwofie, Emmanuel Broni, Bismark Dankwa, Kweku S. Enninful, Joshua Teye, Cedar R. Davidson, Josephine B. Nimely, J. Chioma Orizu, Prakasha Kempaiah, Brijesh Rathi, Brijesh Rathi, Whelton A. Miller, Whelton A. Miller, Whelton A. Miller

Infectious Diseases

Research output: Contribution to journal › Review article › peer-review

Abstract

Organometallic compounds are molecules that contain at least one metal-carbon bond. Due to resistance of the Plasmodium parasite to traditional organic antimalarials, the use of organometallic compounds has become widely adopted in antimalarial drug discovery. Ferroquine, which was developed due to the emergence of chloroquine resistance, is currently the most advanced organometallic antimalarial drug and has paved the way for the development of new organometallic antimalarials. In this review, a general overview of organometallic antimalarial compounds and their antimalarial activity in comparison to purely organic antimalarials are presented. Furthermore, recent developments in the field are discussed, and future applications of this emerging class of therapeutics in antimalarial drug discovery are suggested.

Original language	English (US)
Article number	9414093
Journal	Journal of Chemistry
Volume	2020
DOIs	https://doi.org/10.1155/2020/9414093
State	Published - 2020

ASJC Scopus subject areas

General Chemistry

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10.1155/2020/9414093

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Kwofie, S. K., Kwofie, S. K., Kwofie, S. K., Broni, E., Dankwa, B., Enninful, K. S., Teye, J., Davidson, C. R., Nimely, J. B., Chioma Orizu, J., Kempaiah, P., Rathi, B., Rathi, B., Miller, W. A., Miller, W. A., & Miller, W. A. (2020). Review of Atypical Organometallic Compounds as Antimalarial Drugs. Journal of Chemistry, 2020, Article 9414093. https://doi.org/10.1155/2020/9414093

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title = "Review of Atypical Organometallic Compounds as Antimalarial Drugs",

abstract = "Organometallic compounds are molecules that contain at least one metal-carbon bond. Due to resistance of the Plasmodium parasite to traditional organic antimalarials, the use of organometallic compounds has become widely adopted in antimalarial drug discovery. Ferroquine, which was developed due to the emergence of chloroquine resistance, is currently the most advanced organometallic antimalarial drug and has paved the way for the development of new organometallic antimalarials. In this review, a general overview of organometallic antimalarial compounds and their antimalarial activity in comparison to purely organic antimalarials are presented. Furthermore, recent developments in the field are discussed, and future applications of this emerging class of therapeutics in antimalarial drug discovery are suggested.",

author = "Kwofie, {Samuel K.} and Kwofie, {Samuel K.} and Kwofie, {Samuel K.} and Emmanuel Broni and Bismark Dankwa and Enninful, {Kweku S.} and Joshua Teye and Davidson, {Cedar R.} and Nimely, {Josephine B.} and {Chioma Orizu}, J. and Prakasha Kempaiah and Brijesh Rathi and Brijesh Rathi and Miller, {Whelton A.} and Miller, {Whelton A.} and Miller, {Whelton A.}",

note = "Publisher Copyright: {\textcopyright} 2020 Samuel K. Kwofie et al.",

year = "2020",

doi = "10.1155/2020/9414093",

language = "English (US)",

volume = "2020",

journal = "Journal of Chemistry",

issn = "2090-9063",

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T1 - Review of Atypical Organometallic Compounds as Antimalarial Drugs

AU - Kwofie, Samuel K.

AU - Broni, Emmanuel

AU - Dankwa, Bismark

AU - Enninful, Kweku S.

AU - Teye, Joshua

AU - Davidson, Cedar R.

AU - Nimely, Josephine B.

AU - Chioma Orizu, J.

AU - Kempaiah, Prakasha

AU - Rathi, Brijesh

AU - Miller, Whelton A.

PY - 2020

Y1 - 2020

N2 - Organometallic compounds are molecules that contain at least one metal-carbon bond. Due to resistance of the Plasmodium parasite to traditional organic antimalarials, the use of organometallic compounds has become widely adopted in antimalarial drug discovery. Ferroquine, which was developed due to the emergence of chloroquine resistance, is currently the most advanced organometallic antimalarial drug and has paved the way for the development of new organometallic antimalarials. In this review, a general overview of organometallic antimalarial compounds and their antimalarial activity in comparison to purely organic antimalarials are presented. Furthermore, recent developments in the field are discussed, and future applications of this emerging class of therapeutics in antimalarial drug discovery are suggested.

AB - Organometallic compounds are molecules that contain at least one metal-carbon bond. Due to resistance of the Plasmodium parasite to traditional organic antimalarials, the use of organometallic compounds has become widely adopted in antimalarial drug discovery. Ferroquine, which was developed due to the emergence of chloroquine resistance, is currently the most advanced organometallic antimalarial drug and has paved the way for the development of new organometallic antimalarials. In this review, a general overview of organometallic antimalarial compounds and their antimalarial activity in comparison to purely organic antimalarials are presented. Furthermore, recent developments in the field are discussed, and future applications of this emerging class of therapeutics in antimalarial drug discovery are suggested.

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Review of Atypical Organometallic Compounds as Antimalarial Drugs

Abstract

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