Reversible encephalopathy after cryopreserved peripheral blood stem cell infusion

Madhav Dhodapkar, Stuart L. Goldberg, Ayalew Tefferi, Morse A. Gertz

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


We report two patients who experienced severe reversible encephalopathy following infusion of peripheral blood stem cells cryopreserved in 10% dimethylsulfoxide (DMSO). In one patient, reduction of DMSO level with plasmapheresis resulted in marked improvement in encephalopathy. Infusion of large volumes of cryopreserved stem cells may result in a signiflcant toxlc reaction. Plasmapheresis may be a treatment option for patients with significant toxicity related to DMSO. © 1994 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)187-188
Number of pages2
JournalAmerican journal of hematology
Issue number2
StatePublished - Feb 1994


  • dimethylsulfoxide toxiclty
  • encephalopathy
  • perpheral blood stem cell transplant

ASJC Scopus subject areas

  • Hematology


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