Reversible amantadine-induced corneal edema in an adolescent

Bradley Hughes, Vahid Feiz, Steven B. Flynn, Michael C. Brodsky

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Purpose: To document reversible corneal edema caused by amantadine in a pediatric patient. Methods: A 14-year-old boy with a neurologic tremor was referred for bilateral visual loss. Our examination disclosed bilateral corneal edema without ocular inflammation. Pachymetry confirmed significantly increased corneal thickness above 900 μm. Results: Review of the patient's medical information revealed recent institution of amantadine as a means to control the patient's tremor. On cessation of this agent, rapid resolution of corneal edema and recovery of visual acuity occurred. Repeat pachymetry measurement revealed normal corneal thickness. Conclusion: In cases of corneal edema and in the absence of any identifiable ocular causes, a review of toxic effects of systemic medication should be undertaken. Amantadine can cause corneal decompensation and needs to be considered as part of the differential diagnosis of corneal edema.

Original languageEnglish (US)
Pages (from-to)823-824
Number of pages2
Issue number8
StatePublished - Nov 1 2004


  • Amantadine
  • Corneal edema
  • Drug-induced ocular toxicity
  • Pachymetry

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'Reversible amantadine-induced corneal edema in an adolescent'. Together they form a unique fingerprint.

Cite this