Retrograde transport in corticospinal neurons after spinal cord transection

Earl R. Feringa; H. Lee Vahlsing; Benn E. Smith

doi:10.1212/wnl.33.4.478

Retrograde transport in corticospinal neurons after spinal cord transection

Earl R. Feringa, H. Lee Vahlsing, Benn E. Smith

Neurology

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Complete spinal cord transection at T-6/T-7 in rats caused a decrease in the number of surviving corticospinal neurons. Cell death began 5 and 10 weeks after cord injury. The number of surviving cells decreased progressively for at least 25 weeks after injury. Surviving cells were identified by their ability to transport horseradish peroxidase (HRP) retrograde from a T-1/T-2 insertion site to cortical cell somas. Therapy aimed at promoting corticospinal tract regeneration must be started early after spinal cord injury.

Original language	English (US)
Pages (from-to)	478-482
Number of pages	5
Journal	Neurology
Volume	33
Issue number	4
DOIs	https://doi.org/10.1212/wnl.33.4.478
State	Published - Apr 1983

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.1212/wnl.33.4.478

Cite this

@article{6634480ff9254459b42da03e966c7f5f,

title = "Retrograde transport in corticospinal neurons after spinal cord transection",

abstract = "Complete spinal cord transection at T-6/T-7 in rats caused a decrease in the number of surviving corticospinal neurons. Cell death began 5 and 10 weeks after cord injury. The number of surviving cells decreased progressively for at least 25 weeks after injury. Surviving cells were identified by their ability to transport horseradish peroxidase (HRP) retrograde from a T-1/T-2 insertion site to cortical cell somas. Therapy aimed at promoting corticospinal tract regeneration must be started early after spinal cord injury.",

author = "Feringa, {Earl R.} and Vahlsing, {H. Lee} and Smith, {Benn E.}",

year = "1983",

month = apr,

doi = "10.1212/wnl.33.4.478",

language = "English (US)",

volume = "33",

pages = "478--482",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

TY - JOUR

T1 - Retrograde transport in corticospinal neurons after spinal cord transection

AU - Feringa, Earl R.

AU - Vahlsing, H. Lee

AU - Smith, Benn E.

PY - 1983/4

Y1 - 1983/4

N2 - Complete spinal cord transection at T-6/T-7 in rats caused a decrease in the number of surviving corticospinal neurons. Cell death began 5 and 10 weeks after cord injury. The number of surviving cells decreased progressively for at least 25 weeks after injury. Surviving cells were identified by their ability to transport horseradish peroxidase (HRP) retrograde from a T-1/T-2 insertion site to cortical cell somas. Therapy aimed at promoting corticospinal tract regeneration must be started early after spinal cord injury.

AB - Complete spinal cord transection at T-6/T-7 in rats caused a decrease in the number of surviving corticospinal neurons. Cell death began 5 and 10 weeks after cord injury. The number of surviving cells decreased progressively for at least 25 weeks after injury. Surviving cells were identified by their ability to transport horseradish peroxidase (HRP) retrograde from a T-1/T-2 insertion site to cortical cell somas. Therapy aimed at promoting corticospinal tract regeneration must be started early after spinal cord injury.

UR - http://www.scopus.com/inward/record.url?scp=0020540972&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020540972&partnerID=8YFLogxK

U2 - 10.1212/wnl.33.4.478

DO - 10.1212/wnl.33.4.478

M3 - Article

C2 - 6682195

AN - SCOPUS:0020540972

SN - 0028-3878

VL - 33

SP - 478

EP - 482

JO - Neurology

JF - Neurology

IS - 4

ER -

Retrograde transport in corticospinal neurons after spinal cord transection

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this