Resting state functional MRI in Alzheimer's disease

Prashanthi Vemuri; David T. Jones; Clifford R. Jack

doi:10.1186/alzrt100

Resting state functional MRI in Alzheimer's disease

Prashanthi Vemuri, David T. Jones, Clifford R. Jack

Research output: Contribution to journal › Review article › peer-review

68 Scopus citations

Abstract

Resting-state functional magnetic resonance imaging (fMRI) is emerging as an interesting biomarker for measuring connectivity of the brain in patients with Alzheimer's disease (AD). In this review, we discuss the origins of resting-state fMRI, common methodologies used to extract information from these four-dimensional fMRI scans, and important considerations for the analysis of these scans. Then we present the current state of knowledge in this area by summarizing various AD resting-state fMRI studies presented in the first section and end with a discussion of future developments and open questions in the field.

Original language	English (US)
Article number	2
Journal	Alzheimer's Research and Therapy
Volume	4
Issue number	1
DOIs	https://doi.org/10.1186/alzrt100
State	Published - 2012

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cognitive Neuroscience

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10.1186/alzrt100

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title = "Resting state functional MRI in Alzheimer's disease",

abstract = "Resting-state functional magnetic resonance imaging (fMRI) is emerging as an interesting biomarker for measuring connectivity of the brain in patients with Alzheimer's disease (AD). In this review, we discuss the origins of resting-state fMRI, common methodologies used to extract information from these four-dimensional fMRI scans, and important considerations for the analysis of these scans. Then we present the current state of knowledge in this area by summarizing various AD resting-state fMRI studies presented in the first section and end with a discussion of future developments and open questions in the field.",

author = "Prashanthi Vemuri and Jones, {David T.} and Jack, {Clifford R.}",

note = "Funding Information: PV receives support from National Institute on Aging grant K99 AG37573 (as principal investigator) and an Alzheimer{\textquoteright}s Association New Investigator Research Grant. CRJ receives support from National Institute on Aging grants R01 AG11378 (as principal investigator), P50-AG16574 (as co-investigator), and U01 AG024904-01 (as co-investigator) and the Alexander Family Alzheimer{\textquoteright}s Disease Research Professorship of the Mayo Foundation.",

year = "2012",

doi = "10.1186/alzrt100",

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journal = "Alzheimer's Research and Therapy",

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T1 - Resting state functional MRI in Alzheimer's disease

AU - Vemuri, Prashanthi

AU - Jones, David T.

AU - Jack, Clifford R.

N1 - Funding Information: PV receives support from National Institute on Aging grant K99 AG37573 (as principal investigator) and an Alzheimer’s Association New Investigator Research Grant. CRJ receives support from National Institute on Aging grants R01 AG11378 (as principal investigator), P50-AG16574 (as co-investigator), and U01 AG024904-01 (as co-investigator) and the Alexander Family Alzheimer’s Disease Research Professorship of the Mayo Foundation.

PY - 2012

Y1 - 2012

N2 - Resting-state functional magnetic resonance imaging (fMRI) is emerging as an interesting biomarker for measuring connectivity of the brain in patients with Alzheimer's disease (AD). In this review, we discuss the origins of resting-state fMRI, common methodologies used to extract information from these four-dimensional fMRI scans, and important considerations for the analysis of these scans. Then we present the current state of knowledge in this area by summarizing various AD resting-state fMRI studies presented in the first section and end with a discussion of future developments and open questions in the field.

AB - Resting-state functional magnetic resonance imaging (fMRI) is emerging as an interesting biomarker for measuring connectivity of the brain in patients with Alzheimer's disease (AD). In this review, we discuss the origins of resting-state fMRI, common methodologies used to extract information from these four-dimensional fMRI scans, and important considerations for the analysis of these scans. Then we present the current state of knowledge in this area by summarizing various AD resting-state fMRI studies presented in the first section and end with a discussion of future developments and open questions in the field.

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Resting state functional MRI in Alzheimer's disease

Abstract

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