Response to vitamin D3 supplementation in obese and non-obese caucasian adolescents

Roxana Aguirre Castaneda, Nicole Nader, Amy Weaver, Ravinder Singh, Seema Kumar

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Background/Aims: Vitamin D deficiency is highly prevalent in obese children, and obese children tend to respond poorly to vitamin D supplementation. The objective of the study was to compare the response to vitamin D3 supplementation (2,000 IU once daily for 12 weeks) between obese and non-obese Caucasian adolescents. Methods: The study design was open label non-randomized. It was carried out at a single center. Eighteen obese adolescents (aged 12-18 years) and the same number of age-, gender-and season-matched non-obese adolescents received vitamin D3 (2,000 IU/day) orally for 12 weeks. Total serum 25-hydroxyvitamin D [25(OH)D], parathyroid hormone, calcium and phosphorus were measured at baseline and at the end of the 12-week period. Results: The mean baseline 25(OH)D level was higher in the non-obese compared to the obese subjects (mean 28.9 vs. 25.2 ng/ml; p = 0.029). The increment in 25(OH)D levels following vitamin D supplementation was significantly lower in the obese adolescents (mean change 5.8 vs. 9.8 ng/ml; p = 0.019). Conclusions: Higher doses of vitamin D are required to treat vitamin D deficiency in obese adolescents compared to their non-obese peers.

Original languageEnglish (US)
Pages (from-to)226-231
Number of pages6
JournalHormone Research in Paediatrics
Issue number4
StatePublished - Nov 2012


  • 25-Hydroxyvitamin D
  • Obese adolescents
  • Vitamin D

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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