Response of severe systemic mastocytosis to interferon alpha

J. H. Butterfield

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Six patients with documented systemic mast cell disease were enrolled in a 1-year, phase 1 study to determine the possible benefits of interferon alpha-2b (IFN-α). IFN-α therapy was begun at a dosage of 0.5 million units/day (MU/day) by subcutaneous injection and increased, as tolerated to 3-0 MU/day. Subsequent dose modifications were made based on clinical tolerance and response. No immediate, adverse reactions to IFN-α occurred. Several patients showed symptomatic improvement. In two patients ascites resolved and did not recur. Two other patients reported improved energy levels and had decreased size of retroperitoneal, mesenteric and retrocrural nodes. One patient failed to benefit and died shortly after completing 12 months of therapy. Bone marrow mastocytosis decreased by 5% to 10% after 12 months of therapy with IFN-α. Although five of the six patients had a decrease in the urinary excretion of 1-methyl-4-imidazole acetic acid, serum tryptase values did not appreciably change in any patient. Side-effects from IFN-α included hypothyroidism, thrombocytopenia and depression. It is concluded that although treatment with IFN-α was associated with a decline in bone marrow mastocytosis and reduced excretion of histamine metabolites, prolonged therapy may be needed and dose-limiting side-effects are frequent.

Original languageEnglish (US)
Pages (from-to)489-495
Number of pages7
JournalBritish Journal of Dermatology
Issue number3
StatePublished - 1998

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Response of severe systemic mastocytosis to interferon alpha'. Together they form a unique fingerprint.

Cite this