Residual tumor on wide excisional margins after treatment of invasive melanoma

Maria T. Huayllani, Sanjay P. Bagaria, David J. Restrepo, Daniel Boczar, Andrea Sisti, Jordan J. Cochuyt, Aaron C. Spaulding, Emmanuel M. Gabriel, Brian D. Rinker, Antonio J. Forte

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background/Aim: The surgical management of invasive melanoma has been debated for many years and recommended excisional margins have been established. We aimed to describe the factors and survival related to the presence of residual tumor in patients with invasive melanoma lymph nodes negative. Patients and Methods: We performed a retrospective study by querying the National Cancer Database from 2004 to 2015. Associations were tested using a multivariate analysis. Overall survival was compared using the Kaplan-Meier method. Results: A total of 26,440 patients met the inclusion criteria. For Breslow depth groups ≥1 mm and >2 mm, older age and location in the head and neck were factors associated to residual tumor in margins (p<0.05), whereas only location in the head and neck was associated to residual tumor for patients with Breslow depth between 1.01-2.00 mm (p<0.05). Conclusion: Knowledge of the factors associated with the residual tumor will help establish a patient-centered management and decrease the recurrence of disease.

Original languageEnglish (US)
Pages (from-to)1059-1063
Number of pages5
JournalAnticancer research
Issue number2
StatePublished - 2020


  • Excisional margins
  • Invasive melanoma
  • NCDB
  • Residual tumor
  • Wide excisional surgery

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Residual tumor on wide excisional margins after treatment of invasive melanoma'. Together they form a unique fingerprint.

Cite this