Report of the ECCO workshop on anti-TNF therapy failures in inflammatory bowel diseases: Biological roles and effects of TNF and TNF antagonists

Yehuda Chowers; Andreas Sturm; Miquel Sans; Konstantinos Papadakis; Maria Gazouli; Marcus Harbord; Jörg Jahnel; Gerassimos J. Mantzaris; Johannes Meier; Christian Mottet; Laurent Peyrin-Biroulet; Matthieu Allez

doi:10.1016/j.crohns.2010.05.011

Report of the ECCO workshop on anti-TNF therapy failures in inflammatory bowel diseases: Biological roles and effects of TNF and TNF antagonists

Yehuda Chowers, Andreas Sturm, Miquel Sans, Konstantinos Papadakis, Maria Gazouli, Marcus Harbord, Jörg Jahnel, Gerassimos J. Mantzaris, Johannes Meier, Christian Mottet, Laurent Peyrin-Biroulet, Matthieu Allez

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

This second section of the first ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases addresses the biological roles of TNFα and the effects and mechanisms of action of TNFα antagonists. Mechanisms underlying their failure, including induction of TNF-independent inflammatory pathways and phenomena of paradoxical inflammation are discussed.

Original language	English (US)
Pages (from-to)	367-376
Number of pages	10
Journal	Journal of Crohn's and Colitis
Volume	4
Issue number	4
DOIs	https://doi.org/10.1016/j.crohns.2010.05.011
State	Published - Oct 2010

Keywords

Anti-TNF therapy
Crohn's disease
Inflammatory bowel diseases
Paradoxical inflammation
TNF alpha
Ulcerative colitis

ASJC Scopus subject areas

Gastroenterology

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10.1016/j.crohns.2010.05.011

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Chowers, Y., Sturm, A., Sans, M., Papadakis, K., Gazouli, M., Harbord, M., Jahnel, J., Mantzaris, G. J., Meier, J., Mottet, C., Peyrin-Biroulet, L., & Allez, M. (2010). Report of the ECCO workshop on anti-TNF therapy failures in inflammatory bowel diseases: Biological roles and effects of TNF and TNF antagonists. Journal of Crohn's and Colitis, 4(4), 367-376. https://doi.org/10.1016/j.crohns.2010.05.011

Chowers, Y, Sturm, A, Sans, M, Papadakis, K, Gazouli, M, Harbord, M, Jahnel, J, Mantzaris, GJ, Meier, J, Mottet, C, Peyrin-Biroulet, L & Allez, M 2010, 'Report of the ECCO workshop on anti-TNF therapy failures in inflammatory bowel diseases: Biological roles and effects of TNF and TNF antagonists', Journal of Crohn's and Colitis, vol. 4, no. 4, pp. 367-376. https://doi.org/10.1016/j.crohns.2010.05.011

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abstract = "This second section of the first ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases addresses the biological roles of TNFα and the effects and mechanisms of action of TNFα antagonists. Mechanisms underlying their failure, including induction of TNF-independent inflammatory pathways and phenomena of paradoxical inflammation are discussed.",

keywords = "Anti-TNF therapy, Crohn's disease, Inflammatory bowel diseases, Paradoxical inflammation, TNF alpha, Ulcerative colitis",

author = "Yehuda Chowers and Andreas Sturm and Miquel Sans and Konstantinos Papadakis and Maria Gazouli and Marcus Harbord and J{\"o}rg Jahnel and Mantzaris, {Gerassimos J.} and Johannes Meier and Christian Mottet and Laurent Peyrin-Biroulet and Matthieu Allez",

note = "Funding Information: Y. Chowers has received honorarium from Abbott and Schering Plough. A. Sturm has received honorarium from Abbott, Essex, Falk, Shire, Ferring, UCB, and Merckle-Recordati, and received scientific grants from ArdeyPharm, Travacare, and Fresenius. M.Sans has received honorarium from Faes Farma, Chiesi, Biotoscana, UCB Pharma, Shering-Plough, Abbott, Astra and Almirall. G.Mantzaris, has received honorarium from Centocor Ortho Biotech, Ferring International, Schering-Plough, Abbott Immunology, Schering-Plough Hellas, and Abbott Hellas. L.Peyrin-Biroulet has received honorarium from Abbott Laboratories, Centocor and UCB Pharma, and grant support from UCB Pharma. M Allez has received honorarium from Abbott, Schering-Plough, UCB, Ferring, Janssen-Cilag and Novo-Nordisk. ",

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doi = "10.1016/j.crohns.2010.05.011",

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AU - Papadakis, Konstantinos

AU - Gazouli, Maria

AU - Harbord, Marcus

AU - Jahnel, Jörg

AU - Mantzaris, Gerassimos J.

AU - Meier, Johannes

AU - Mottet, Christian

AU - Peyrin-Biroulet, Laurent

AU - Allez, Matthieu

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Report of the ECCO workshop on anti-TNF therapy failures in inflammatory bowel diseases: Biological roles and effects of TNF and TNF antagonists

Abstract

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