TY - JOUR
T1 - Replication-Coupled Nucleosome Assembly in the Passage of Epigenetic Information and Cell Identity
AU - Serra-Cardona, Albert
AU - Zhang, Zhiguo
N1 - Funding Information:
We thank Dr Jessica Tyler for helpful discussion and suggestions. This work is supported by the National Institutes of Health (NIH; grant R35 GM118015 ). We apologize to those whose work could not be cited owing to space limitations.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/2
Y1 - 2018/2
N2 - During S phase, replicated DNA must be assembled into nucleosomes using both newly synthesized and parental histones in a process that is tightly coupled to DNA replication. This DNA replication-coupled process is regulated by multitude of histone chaperones as well as by histone-modifying enzymes. In recent years novel insights into nucleosome assembly of new H3–H4 tetramers have been gained through studies on the classical histone chaperone CAF-1 and the identification of novel factors involved in this process. Moreover, in vitro reconstitution of chromatin replication has shed light on nucleosome assembly of parental H3–H4, a process that remains elusive. Finally, recent studies have revealed that the replication-coupled nucleosome assembly is important for the determination and maintenance of cell fate in multicellular organisms.
AB - During S phase, replicated DNA must be assembled into nucleosomes using both newly synthesized and parental histones in a process that is tightly coupled to DNA replication. This DNA replication-coupled process is regulated by multitude of histone chaperones as well as by histone-modifying enzymes. In recent years novel insights into nucleosome assembly of new H3–H4 tetramers have been gained through studies on the classical histone chaperone CAF-1 and the identification of novel factors involved in this process. Moreover, in vitro reconstitution of chromatin replication has shed light on nucleosome assembly of parental H3–H4, a process that remains elusive. Finally, recent studies have revealed that the replication-coupled nucleosome assembly is important for the determination and maintenance of cell fate in multicellular organisms.
KW - DNA replication
KW - cell fate maintenance
KW - epigenetic inheritance
KW - histone modifications
KW - nucleosome assembly
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U2 - 10.1016/j.tibs.2017.12.003
DO - 10.1016/j.tibs.2017.12.003
M3 - Review article
AN - SCOPUS:85039549313
SN - 0968-0004
VL - 43
SP - 136
EP - 148
JO - Trends in biochemical sciences
JF - Trends in biochemical sciences
IS - 2
ER -