Replication-Coupled Nucleosome Assembly in the Passage of Epigenetic Information and Cell Identity

Albert Serra-Cardona, Zhiguo Zhang

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


During S phase, replicated DNA must be assembled into nucleosomes using both newly synthesized and parental histones in a process that is tightly coupled to DNA replication. This DNA replication-coupled process is regulated by multitude of histone chaperones as well as by histone-modifying enzymes. In recent years novel insights into nucleosome assembly of new H3–H4 tetramers have been gained through studies on the classical histone chaperone CAF-1 and the identification of novel factors involved in this process. Moreover, in vitro reconstitution of chromatin replication has shed light on nucleosome assembly of parental H3–H4, a process that remains elusive. Finally, recent studies have revealed that the replication-coupled nucleosome assembly is important for the determination and maintenance of cell fate in multicellular organisms.

Original languageEnglish (US)
Pages (from-to)136-148
Number of pages13
JournalTrends in biochemical sciences
Issue number2
StatePublished - Feb 2018


  • DNA replication
  • cell fate maintenance
  • epigenetic inheritance
  • histone modifications
  • nucleosome assembly

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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