Repeat Radiation in the Brain: Managing Patients With Locally Recurrent Glioma

Daniel M. Trifiletti, Timothy D. Malouff, Susan L. McGovern, Shiao Pei Weathers, Tony J.C. Wang, Andrew B. Lassman, Daniel P. Cahill, Helen A. Shih, Paul D. Brown

Research output: Contribution to journalReview articlepeer-review


Treatment of recurrent gliomas is especially challenging, as many of these patients have previously been treated with extensive surgery, radiation, or systemic therapy. Due to this, the optimum therapy for patients with recurrent glioma is controversial, with widely variable practice patterns. In this opinion piece, a multidisciplinary panel of experts provides rationale for their treatment approach in a patient with recurrent glioma following subtotal resection with adjuvant chemoradiation for an anaplastic astrocytoma. In summary, the consensus of the panel was to recommend re-resection if possible with hypofractionated radiotherapy schedules, with re-irradiation and systemic therapy as directed by a multidisciplinary team through repeat analysis of the tumor specimen for an updated mutational burden.

Original languageEnglish (US)
Pages (from-to)218-222
Number of pages5
JournalSeminars in Radiation Oncology
Issue number3
StatePublished - Jul 2020

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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