Renal monoclonal immunoglobulin deposition disease: A report of 64 patients from a single institution

Samih H. Nasr, Anthony M. Valeri, Lynn D. Cornell, Mary E. Fidler, Sanjeev Sethi, Vivette D. D'Agati, Nelson Leung

Research output: Contribution to journalArticlepeer-review

168 Scopus citations


Background and objectives To better define the clinical-pathologic spectrum and prognosis of monoclonal immunoglobulin deposition disease (MIDD), this study reports the largest series. Design, setting, participants, & measurements Characteristics of 64 MIDD patients who were seen at Mayo Clinic are provided. Results Of 64 patients with MIDD, 51 had light chain deposition disease, 7 had heavy chain deposition disease, and6had lightandheavy chaindeposition disease.Themean ageatdiagnosis was 56 years,and23patients (36%) were ≤50 years of age. Clinical evidence of dysproteinemia was present in 62 patients (97%), including multiple myeloma in 38 (59%). M-spike was detected on serum protein electrophoresis in 47 (73%). Serum free light chain ratio was abnormal in all 51 patients tested. Presentation included renal insufficiency, proteinuria, hematuria, and hypertension. Nodular mesangial sclerosis was seen in 39 patients (61%). During a median of 25 months of follow-up (range, 1-140) in 56 patients, 32 (57%) had stable/improved renal function, 2 (4%) had worsening renal function, and 22 (39%) progressed to ESRD. The mean renal and patient survivals were 64 and 90 months, respectively. The disease recurred in three of four patients who received a kidney transplant. Conclusions Patients with MIDD generally present at a younger age than those with light chain amyloidosis or light chain cast nephropathy. Serum free light chain ratio is abnormal in all MIDD patients, whereas only three-quarters have abnormal serum protein electrophoresis. The prognosis for MIDD is improving compared with historical controls, likely reflecting earlier detection and improved therapies.

Original languageEnglish (US)
Pages (from-to)231-239
Number of pages9
JournalClinical Journal of the American Society of Nephrology
Issue number2
StatePublished - Feb 1 2012

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation


Dive into the research topics of 'Renal monoclonal immunoglobulin deposition disease: A report of 64 patients from a single institution'. Together they form a unique fingerprint.

Cite this