Renal disease associated with monoclonal gammopathy

Nelson Leung, Samih H. Nasr

Research output: Chapter in Book/Report/Conference proceedingChapter


Increasingly, monoclonal gammopathy is recognized as a cause of kidney disease regardless of the hematologic malignancy. As a result, the term monoclonal gammopathy of renal significance (MGRS) has been introduced to distinguish these patients from those with the benign monoclonal gammopathy of undetermined significance. Kidney diseases of MGRS can be classified according to the type of deposits in the kidney. The three major categories are organized (which including fibrillar, microtubular, and crystalline), non-organized, and none. Another characteristic of MGRS-associated nephropathies is their high rate of recurrence after kidney transplant. It is therefore important that kidney transplant recipient be properly treated prior to kidney transplantation. This requires confirmation that a MGRS is responsible for the disease, which can only be done by a kidney biopsy. The treatment should optimally target the clone producing the MGRS rather than be based on renal histology.

Original languageEnglish (US)
Title of host publicationBiology and Management of Unusual Plasma Cell Dyscrasias
PublisherSpringer New York
Number of pages32
ISBN (Electronic)9781441968487
ISBN (Print)9781441968470
StatePublished - Jan 1 2016


  • Amyloidosis
  • Dysproteinemia
  • Fanconi syndrome
  • Immunotactoid glomerulonephritis
  • Monoclonal gammopathy of renal significance
  • Monoclonal immunoglobulin deposition disease

ASJC Scopus subject areas

  • General Medicine


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