Relationship of Q-sweat to quantitative sudomotor axon reflex test (QSART) volumes

David M. Sletten, Stephen D. Weigand, Phillip A. Low

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Q-Sweat, a commercial quantitative sweat measurement system, is modeled on quantitative sudomotor axon reflex testing (QSART). This study investigated the sweat response using Q-Sweat and Mayo-QSART recordings under identical conditions in healthy normal controls. Ninety-four participants were recruited for this study. All participants underwent randomized bilateral QSART recordings over the four standard recording regions. For both men and women, Wilcoxon signed rank tests of paired differences showed significantly lower volumes at each of the four sites for Q-Sweat vs. Mayo-QSART. Linear regression analysis was used to estimate the relationship between Q-Sweat and Mayo-QSART volume measurements separately for men and women. Although there was variability about the regression lines, these fitted models can be used to estimate the expected Mayo-QSART volume given an observed Q-Sweat volume, although it is preferable to use the Q-Sweat normative database directly. We hypothesize that the constant-current generator used in conjunction with Q-Sweat provides a less efficient iontophoresis of acetylcholine than the Mayo-constructed constant-current stimulator and results in lower volumes.

Original languageEnglish (US)
Pages (from-to)240-246
Number of pages7
JournalMuscle and Nerve
Issue number2
StatePublished - Feb 2010


  • Autonomic function
  • Autonomic testing
  • Q-Sweat
  • Sudomotor

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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