Relationship Between Severity of Hyperglycemia and Metabolic Acidosis in Diabetic Ketoacidosis

KATHY R. BRANDT; JOHN M. MILES

doi:10.1016/S0025-6196(12)65501-3

Relationship Between Severity of Hyperglycemia and Metabolic Acidosis in Diabetic Ketoacidosis

KATHY R. BRANDT, JOHN M. MILES

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Abstract

We evaluated 114 hospital admissions for diabetic ketoacidosis (occurring in 78 patients) retrospectively by using the Mayo Clinic medical records system. Initial plasma glucose and serum bicarbonate values were examined by using regression analysis. No correlation was found between these two measurements (r = −0.03). The reason for this dissociation between hyperglycemia and hyperketonemia needs further elucidation, but it may be related to impaired hepatic glucose production in some patients.

Original language	English (US)
Pages (from-to)	1071-1074
Number of pages	4
Journal	Mayo Clinic proceedings
Volume	63
Issue number	11
DOIs	https://doi.org/10.1016/S0025-6196(12)65501-3
State	Published - 1988

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Medicine(all)

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10.1016/S0025-6196(12)65501-3

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abstract = "We evaluated 114 hospital admissions for diabetic ketoacidosis (occurring in 78 patients) retrospectively by using the Mayo Clinic medical records system. Initial plasma glucose and serum bicarbonate values were examined by using regression analysis. No correlation was found between these two measurements (r = −0.03). The reason for this dissociation between hyperglycemia and hyperketonemia needs further elucidation, but it may be related to impaired hepatic glucose production in some patients.",

author = "BRANDT, {KATHY R.} and MILES, {JOHN M.}",

note = "Funding Information: This study was supported in part by the Mayo Foundation and by Grant DK 38092 from the National Institutes of Health, Public Health Service. ",

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AU - BRANDT, KATHY R.

AU - MILES, JOHN M.

N1 - Funding Information: This study was supported in part by the Mayo Foundation and by Grant DK 38092 from the National Institutes of Health, Public Health Service.

PY - 1988

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N2 - We evaluated 114 hospital admissions for diabetic ketoacidosis (occurring in 78 patients) retrospectively by using the Mayo Clinic medical records system. Initial plasma glucose and serum bicarbonate values were examined by using regression analysis. No correlation was found between these two measurements (r = −0.03). The reason for this dissociation between hyperglycemia and hyperketonemia needs further elucidation, but it may be related to impaired hepatic glucose production in some patients.

AB - We evaluated 114 hospital admissions for diabetic ketoacidosis (occurring in 78 patients) retrospectively by using the Mayo Clinic medical records system. Initial plasma glucose and serum bicarbonate values were examined by using regression analysis. No correlation was found between these two measurements (r = −0.03). The reason for this dissociation between hyperglycemia and hyperketonemia needs further elucidation, but it may be related to impaired hepatic glucose production in some patients.

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Relationship Between Severity of Hyperglycemia and Metabolic Acidosis in Diabetic Ketoacidosis

Abstract

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