Relation of vertebral deformities to bone density, structure, and strength

L. Joseph Melton, B. Lawrence Riggs, Tony M. Keaveny, Sara J. Achenbach, David Kopperdahl, Jon J. Camp, Peggy A. Rouleau, Shreyasee Amin, Elizabeth J. Atkinson, Richard A. Robb, Terry M. Therneau, Sundeep Khosla

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Because they are not reliably discriminated by areal bone mineral density (aBMD) measurements, it is unclear whether minimal vertebral deformities represent early osteoporotic fractures. To address this, we compared 90 postmenopausal women with no deformity (controls) with 142 women with one or more semiquantitative grade 1 (mild) deformities and 51 women with any grade 2-3 (moderate/ severe) deformities. aBMD was measured by dual-energy X-ray absorptiometry (DXA), lumbar spine volumetric bone mineral density (vBMD) and geometry by quantitative computed tomography (QCT), bone microstructure by high-resolution peripheral QCT at the radius (HRpQCT), and vertebral compressive strength and load-to-strength ratio by finite-element analysis (FEA) of lumbar spine QCT images. Compared with controls, women with grade 1 deformities had significantly worse values for many bone density, structure, and strength parameters, although deficits all were much worse for the women with grade 2-3 deformities. Likewise, these skeletal parameters were more strongly associated with moderate to severe than with mild deformities by age-adjusted logistic regression. Nonetheless, grade 1 vertebral deformities were significantly associated with four of the five main variable categories assessed: bone density (lumbar spine vBMD), bone geometry (vertebral apparent cortical thickness), bone strength (overall vertebral compressive strength by FEA), and load-to-strength ratio (45-degree forward bending ÷ vertebral compressive strength). Thus significantly impaired bone density, structure, and strength compared with controls indicate that many grade 1 deformities do represent early osteoporotic fractures, with corresponding implications for clinical decision making.

Original languageEnglish (US)
Pages (from-to)1922-1930
Number of pages9
JournalJournal of Bone and Mineral Research
Issue number9
StatePublished - Sep 2010


  • Bone density
  • Bone quality
  • Finite-element analysis
  • QCT
  • Vertebral fracture

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine


Dive into the research topics of 'Relation of vertebral deformities to bone density, structure, and strength'. Together they form a unique fingerprint.

Cite this