Reinnervation post-heart transplantation

Avishay Grupper, Henry Gewirtz, Sudhir Kushwaha

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Heart transplantation results in complete denervation of the donor heart with loss of afferent and efferent nerve connections. The majority of patients remain completely denervated during the first 6-12 months following transplantation. Evidence of reinnervation is usually found during the second year after transplantation and involve the myocardial muscle, sinoatrial node, and coronary vessels, but remains incomplete and regionally limited many years post-transplant. Restoration of cardiac innervation can improve exercise capacity as well as blood flow regulation in the coronary arteries, and hence improve quality of life. As yet, there is no evidence that the reinnervation process is associated with the occurrence of allograft-related events or survival.

Original languageEnglish (US)
Pages (from-to)1799-1806
Number of pages8
JournalEuropean heart journal
Issue number20
StatePublished - May 21 2018


  • Cardiac denervation
  • Cardiac reinnervation
  • Heart transplantation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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