TY - JOUR
T1 - Regulation of the T-independent humoral response by TACI
AU - Von Bülow, Götz Ulrich
AU - Van Deursen, Jan M.
AU - Bram, Richard J.
PY - 2001
Y1 - 2001
N2 - TACI is a TNFR homolog expressed by mature B lymphocytes that has been implicated in the positive regulation of B cell growth and antibody production, as well as in the development of autoimmune disease. Its biology is complex due to the existence of two ligands, BLyS and APRIL, and a homologous receptor, BCMA, that similarly binds both ligands. To determine its critical biological role, we generated TACI knockout mice. Surprisingly, these mice demonstrated a 2-fold increase in numbers of circulating and splenic B cells, apparently due to increased proliferation rate. Maturation of B cells and T-dependent antibody production was normal, but responses to T-independent type II antigens were almost completely abolished. It appears that TACI provides an essential costimulatory signal for the T-independent humoral response.
AB - TACI is a TNFR homolog expressed by mature B lymphocytes that has been implicated in the positive regulation of B cell growth and antibody production, as well as in the development of autoimmune disease. Its biology is complex due to the existence of two ligands, BLyS and APRIL, and a homologous receptor, BCMA, that similarly binds both ligands. To determine its critical biological role, we generated TACI knockout mice. Surprisingly, these mice demonstrated a 2-fold increase in numbers of circulating and splenic B cells, apparently due to increased proliferation rate. Maturation of B cells and T-dependent antibody production was normal, but responses to T-independent type II antigens were almost completely abolished. It appears that TACI provides an essential costimulatory signal for the T-independent humoral response.
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U2 - 10.1016/S1074-7613(01)00130-3
DO - 10.1016/S1074-7613(01)00130-3
M3 - Article
C2 - 11371359
AN - SCOPUS:0035004320
SN - 1074-7613
VL - 14
SP - 573
EP - 582
JO - Immunity
JF - Immunity
IS - 5
M1 - 129
ER -