Regulation of human b lymphocyte responsiveness

P. E. Lipsky, S. Hirohata, D. F. Jelinek, L. Mcanally, J. B. Splawski

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Regulation of human B cell responses is a complex process involving the activities of a variety of cells and cytokines. There are important differences between the regulation of human and murine B lymphocytes, especially with regard to the action of IL2 and IL4. In man, IL2 appears to play a central role in regulating B cell activation, proliferation and differentiation, whereas ILA plays a regulatory role by inhibiting initial B cell activation. Above and beyond providing regulatoly cytokines, activated human T cells can also directly stimulate B cell differentiation by a process that requires cellular contact. A better understanding of the nature of signal transduction during interactions between B cells and activated T cells and provided by the various cytokines should provide additional insight into the regulation of B cell function in man.

Original languageEnglish (US)
Pages (from-to)229-235
Number of pages7
JournalScandinavian Journal of Rheumatology
Issue numberS76
StatePublished - 1988


  • B lymphocytes
  • Helper T cells
  • Ig secreting cells
  • Interleukin 2
  • Interleukin 4

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology


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