Regulation of histone gene expression

Gary S. Stein, Janet L. Stein, Andre J. van Wijnen, Jane B. Lian

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Histone genes are expressed during the S phase of the cell cycle. Control is at multiple levels and is mediated by the integration of regulatory signals in response to cell-cycle progression and the onset of differentiation. Much work has been carried out on the H4 gene promoter, which appears to be organized into a series of distinct regulatory elements. The three-dimensional organization of the promoter and, in particular, its spatial relationship with the nuclear matrix scaffold, may be important factors of transcription regulation.

Original languageEnglish (US)
Pages (from-to)166-173
Number of pages8
JournalCurrent Opinion in Cell Biology
Issue number2
StatePublished - Apr 1992

ASJC Scopus subject areas

  • Cell Biology


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