Regulation of function of transplanted parathyroid glands in man

Arthur B. Schneider; Samuel A. Wells; J. Caulie Gunnells; John B. Leslie; Louis M. Sherwood

doi:10.1016/0002-9343(77)90156-5

Regulation of function of transplanted parathyroid glands in man

Arthur B. Schneider, Samuel A. Wells, J. Caulie Gunnells, John B. Leslie, Louis M. Sherwood

Anesthesiology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The results of studies performed in nine patients who had undergone successful parathyroidectomy and gland transplantation are presented. Transplantation of parathyroid tissue to the forearm, performed for therapeutic reasons, provided a unique opportunity to sample parathyroid gland effluent and to assess secretory function in vivo. The relationship of calcium to immunoreactive parathyroid hormone (iPTH) release was studied during calcium and ethylenediamine tetraacetic acid (EDTA) infusions as well as dialysis against a low calcium bath (low calcium dialysis) in patients with chronic renal failure. Calcium infusions caused an abrupt decrease in hormone release down to a persistent base line within 30 minutes, whereas EDTA infusion caused a sharp increase which peaked between 30 to 60 minutes and returned towards base line despite continuation of the hypocalcemic stimulus. Low calcium dialysis caused an irregular release of hormone which appeared to deplete gland reserves during the period of the stimulus. Ready access to the venous effluent of the transplanted tissue makes this an excellent model for studying parathyroid physiology in man.

Original language	English (US)
Pages (from-to)	710-718
Number of pages	9
Journal	The American Journal of Medicine
Volume	63
Issue number	5
DOIs	https://doi.org/10.1016/0002-9343(77)90156-5
State	Published - Nov 1977

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/0002-9343(77)90156-5

Cite this

@article{f3d80598439d47c4bf4fb959912653c8,

title = "Regulation of function of transplanted parathyroid glands in man",

abstract = "The results of studies performed in nine patients who had undergone successful parathyroidectomy and gland transplantation are presented. Transplantation of parathyroid tissue to the forearm, performed for therapeutic reasons, provided a unique opportunity to sample parathyroid gland effluent and to assess secretory function in vivo. The relationship of calcium to immunoreactive parathyroid hormone (iPTH) release was studied during calcium and ethylenediamine tetraacetic acid (EDTA) infusions as well as dialysis against a low calcium bath (low calcium dialysis) in patients with chronic renal failure. Calcium infusions caused an abrupt decrease in hormone release down to a persistent base line within 30 minutes, whereas EDTA infusion caused a sharp increase which peaked between 30 to 60 minutes and returned towards base line despite continuation of the hypocalcemic stimulus. Low calcium dialysis caused an irregular release of hormone which appeared to deplete gland reserves during the period of the stimulus. Ready access to the venous effluent of the transplanted tissue makes this an excellent model for studying parathyroid physiology in man.",

author = "Schneider, {Arthur B.} and Wells, {Samuel A.} and Gunnells, {J. Caulie} and Leslie, {John B.} and Sherwood, {Louis M.}",

note = "Funding Information: From the Department of Medicine, Michael Reese Hospital and Medical Center and the Pritzker School of Medicine, University of Chicago, Chicago, Illinois; and the Departments of Surgery and Medicine, Duke University School of Medicine, Durham, North Carolina. This work was supported in part by grants from the U.S. Public Health Service (AM 19263 and HD 08225), the John A. Hartford Foundation, Inc. and the General Clinical Resources Center Program (RR-30) of the Division of Research Resources. Requests for reprints should be addressed to Dr. Arthur Schneider, Department of Medicine, Michael Reese Hospital, 29th Street and Ellis Avenue, Chicago, Illinois 60616. Manuscript accepted January 12, 1977. l Recipient of a Research Career Development Award (K04 AM00103) from the U.S. Public Health Service. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1977",

month = nov,

doi = "10.1016/0002-9343(77)90156-5",

language = "English (US)",

volume = "63",

pages = "710--718",

journal = "The American Journal of Medicine",

issn = "0002-9343",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Regulation of function of transplanted parathyroid glands in man

AU - Schneider, Arthur B.

AU - Wells, Samuel A.

AU - Gunnells, J. Caulie

AU - Leslie, John B.

AU - Sherwood, Louis M.

N1 - Funding Information: From the Department of Medicine, Michael Reese Hospital and Medical Center and the Pritzker School of Medicine, University of Chicago, Chicago, Illinois; and the Departments of Surgery and Medicine, Duke University School of Medicine, Durham, North Carolina. This work was supported in part by grants from the U.S. Public Health Service (AM 19263 and HD 08225), the John A. Hartford Foundation, Inc. and the General Clinical Resources Center Program (RR-30) of the Division of Research Resources. Requests for reprints should be addressed to Dr. Arthur Schneider, Department of Medicine, Michael Reese Hospital, 29th Street and Ellis Avenue, Chicago, Illinois 60616. Manuscript accepted January 12, 1977. l Recipient of a Research Career Development Award (K04 AM00103) from the U.S. Public Health Service. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1977/11

Y1 - 1977/11

N2 - The results of studies performed in nine patients who had undergone successful parathyroidectomy and gland transplantation are presented. Transplantation of parathyroid tissue to the forearm, performed for therapeutic reasons, provided a unique opportunity to sample parathyroid gland effluent and to assess secretory function in vivo. The relationship of calcium to immunoreactive parathyroid hormone (iPTH) release was studied during calcium and ethylenediamine tetraacetic acid (EDTA) infusions as well as dialysis against a low calcium bath (low calcium dialysis) in patients with chronic renal failure. Calcium infusions caused an abrupt decrease in hormone release down to a persistent base line within 30 minutes, whereas EDTA infusion caused a sharp increase which peaked between 30 to 60 minutes and returned towards base line despite continuation of the hypocalcemic stimulus. Low calcium dialysis caused an irregular release of hormone which appeared to deplete gland reserves during the period of the stimulus. Ready access to the venous effluent of the transplanted tissue makes this an excellent model for studying parathyroid physiology in man.

AB - The results of studies performed in nine patients who had undergone successful parathyroidectomy and gland transplantation are presented. Transplantation of parathyroid tissue to the forearm, performed for therapeutic reasons, provided a unique opportunity to sample parathyroid gland effluent and to assess secretory function in vivo. The relationship of calcium to immunoreactive parathyroid hormone (iPTH) release was studied during calcium and ethylenediamine tetraacetic acid (EDTA) infusions as well as dialysis against a low calcium bath (low calcium dialysis) in patients with chronic renal failure. Calcium infusions caused an abrupt decrease in hormone release down to a persistent base line within 30 minutes, whereas EDTA infusion caused a sharp increase which peaked between 30 to 60 minutes and returned towards base line despite continuation of the hypocalcemic stimulus. Low calcium dialysis caused an irregular release of hormone which appeared to deplete gland reserves during the period of the stimulus. Ready access to the venous effluent of the transplanted tissue makes this an excellent model for studying parathyroid physiology in man.

UR - http://www.scopus.com/inward/record.url?scp=0017724284&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017724284&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(77)90156-5

DO - 10.1016/0002-9343(77)90156-5

M3 - Article

C2 - 412421

AN - SCOPUS:0017724284

SN - 0002-9343

VL - 63

SP - 710

EP - 718

JO - The American Journal of Medicine

JF - The American Journal of Medicine

IS - 5

ER -

Regulation of function of transplanted parathyroid glands in man

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this