Regulating the adaptive immune response to respiratory virus infection

Thomas J. Braciale, Jie Sun, Taeg S. Kim

Research output: Contribution to journalReview articlepeer-review

210 Scopus citations


Recent years have seen several advances in our understanding of immunity to virus infection of the lower respiratory tract, including to influenza virus infection. Here, we review the cellular targets of viruses and the features of the host immune response that are unique to the lungs. We describe the interplay between innate and adaptive immune cells in the induction, expression and control of antiviral immunity, and discuss the impact of the infected lung milieu on moulding the response of antiviral effector T cells. Recent findings on the mechanisms that underlie the increased frequency of severe pulmonary bacterial infections following respiratory virus infection are also discussed.

Original languageEnglish (US)
Pages (from-to)295-305
Number of pages11
JournalNature Reviews Immunology
Issue number4
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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