TY - JOUR
T1 - Regional white matter hyperintensities in posterior cortical atrophy and logopenic progressive aphasia
AU - Pham, Nha Trang Thu
AU - Graff-Radford, Jonathan
AU - Machulda, Mary M.
AU - Spychalla, Anthony J.
AU - Schwarz, Christopher G.
AU - Senjem, Matthew L.
AU - Lowe, Val J.
AU - Vemuri, Prashanthi
AU - Kantarci, Kejal
AU - Knopman, David S.
AU - Petersen, Ronald C.
AU - Jack, Clifford R.
AU - Josephs, Keith A.
AU - Whitwell, Jennifer L.
N1 - Funding Information:
This study was funded by NIH grants R01-AG50603 , R01-DC010367 , and P30-AG062677 , and the Alzheimer's Association grant NIRG-12-242215 .
Publisher Copyright:
© 2022
PY - 2022/11
Y1 - 2022/11
N2 - White matter hyperintensities (WMH) are markers of cerebral small vessel disease and are associated with higher risk of typical amnestic Alzheimer's disease (tAD). Little is known about the frequency and distribution of WMH in atypical variants of AD, including logopenic progressive aphasia (LPA) and posterior cortical atrophy (PCA). We investigated WMHs in 75 LPA, 39 PCA, and 50 tAD patients and associations with age, beta-amyloid PET burden, and cognition. PCA had greater subcortical WMHs in right occipital, parietal, and temporal lobes compared to LPA, and greater parieto-occipital subcortical and occipital periventricular WMHs than tAD. LPA had greater subcortical WMHs in left parietal lobe and deep white matter WMHs than PCA, and greater fronto-occipital subcortical and occipital periventricular WMHs than tAD. Total WMH increased with increasing age but was not related to beta-amyloid burden. Greater WMH was associated with visuoperceptual performance in LPA and PCA after correcting for atrophy. WMH topography differs across AD variants. Further work is needed to determine whether they reflect cerebrovascular disease or regionally specific neurodegenerative changes.
AB - White matter hyperintensities (WMH) are markers of cerebral small vessel disease and are associated with higher risk of typical amnestic Alzheimer's disease (tAD). Little is known about the frequency and distribution of WMH in atypical variants of AD, including logopenic progressive aphasia (LPA) and posterior cortical atrophy (PCA). We investigated WMHs in 75 LPA, 39 PCA, and 50 tAD patients and associations with age, beta-amyloid PET burden, and cognition. PCA had greater subcortical WMHs in right occipital, parietal, and temporal lobes compared to LPA, and greater parieto-occipital subcortical and occipital periventricular WMHs than tAD. LPA had greater subcortical WMHs in left parietal lobe and deep white matter WMHs than PCA, and greater fronto-occipital subcortical and occipital periventricular WMHs than tAD. Total WMH increased with increasing age but was not related to beta-amyloid burden. Greater WMH was associated with visuoperceptual performance in LPA and PCA after correcting for atrophy. WMH topography differs across AD variants. Further work is needed to determine whether they reflect cerebrovascular disease or regionally specific neurodegenerative changes.
KW - Fluid-attenuated inversion recovery
KW - Logopenic progressive aphasia
KW - Magnetic resonance imaging
KW - Posterior cortical atrophy
KW - White matter hyperintensity
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U2 - 10.1016/j.neurobiolaging.2022.07.008
DO - 10.1016/j.neurobiolaging.2022.07.008
M3 - Article
C2 - 35970009
AN - SCOPUS:85135772224
SN - 0197-4580
VL - 119
SP - 46
EP - 55
JO - Neurobiology of aging
JF - Neurobiology of aging
ER -