Regional time-density measurement of myocardial perfusion

Christian D. Eusemann, Jerome F. Breen, Richard A. Robb

Research output: Contribution to journalConference articlepeer-review


The measurement of time-density relationships of the myocardium in studies of Magnetic Resonance perfusion data sets is a clinical technique used in assessing myocardial perfusion. Traditionally, to measure the time-density relationship a physician draws a region on the same 2-D image of the myocardium in sequential cardiac cycles. Throughout multiple cardiac cycles the density changes in this region are measured. A major limitation of this technique is change in anatomy relative to the selected region on the myocardium during consecutive cardiac cycles. This causes measurement errors, which are amplified if the traced region does not encompass the entire myocardial thickness, or includes a boundary exterior to the epicardial or endocardial surface. The technique described in this paper uses approximately the same myocardial region throughout the entire perfusion study, which insures inclusion of the entire endocardial to epicardial region and exclusion of exterior regions. Moreover, this region can be subdivided into smaller regions of interest. This can be accomplished by careful segmentation and reformatting of the data into polar coordinates. This allows sectioning both axially and transaxially through the myocardium permitting regional assessment of perfusion specific values such as maximum and/or the time to reach maximum density. These values can then be illustrated using density-mapped colors or time-density curves. This measurement and display technique may provide enhanced detection and evaluation of regional deficits in myocardial contractility and perfusion.

Original languageEnglish (US)
Pages (from-to)234-241
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Sep 19 2003
EventMedical Imaging 2003: Physiology and Function: Methods, Systems, and Applications - San Diego, CA, United States
Duration: Feb 16 2003Feb 18 2003


  • Cardiac dynamics
  • Functional mapping
  • Local heart motion analysis
  • Myocardial perfusion
  • Partial volume effect
  • Time-density relationship

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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