Regional myocardial blood flow and glucose utilization during fasting and physiological hyperinsulinemia in humans

Patricia Iozzo, Panithaya Chareonthaitawee, Marco Di Terlizzi, D. John Betteridge, Ele Ferrannini, Paolo G. Camici

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43 Scopus citations


We investigated the effect of insulin on total and regional myocardial blood flow (MBF) and glucose uptake (MGU) in healthy subjects (50 ± 5 yr) by means of positron emission tomography (PET) with oxygen-15-labeled water (H215O) and fluorine-18 labeled fluorodeoxyglucose (18FDG) before and during physiological hyperinsulinemia (40 mU·min-1·m-2). Twelve male subjects were included in the study. During hyperinsulinemia, MBF increased from 0.91 ± 0.28 to 1.01 ± 0.31 ml·min-1·g-1 (n = 7 patients, P = 0.05; n = 112 regions, P < 0.005). Intersubject variability ranged from -3.0 to +41%. MGU increased from 0.11 ± 0.08 (n = 5) to 0.56 ± 0.08 μmol·min-1·g-1 (P < 0.0001, n = 7). MBF and insulin-mediated MGU were higher in the septum and anterior and lateral wall along short-axis regions of the heart. During hyperinsulinemia, MBF was also higher in the apex and midventricle compared with the base. MBF and MGU were positively correlated before (r = 0.66, P < 0.0001) and during hyperinsulinemia (r = 0.24, P < 0.05). These results provide evidence that insulin stimulates MBF in normal human hearts and appears to involve mainly those regions of the heart where insulin-mediated MGU is higher. Furthermore, regional distribution of insulin-stimulated MBF and MGU does not appear to be uniform across the left ventricular wall of healthy subjects.

Original languageEnglish (US)
Pages (from-to)E1163-E1171
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Issue number5 45-5
StatePublished - 2002


  • Diabetes mellitus
  • Insulin
  • Positron emission tomography

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)


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