Regional differences in oesophageal motor function

J. L. Wise, J. A. Murray, J. L. Conklin

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


We tested the hypotheses that oesophageal bolus transit and motor function vary regionally, with bolus viscosity and with body position. In healthy volunteers, we measured the bolus head advance time, bolus presence time and bolus transit time in the proximal and distal oesophagus using water and viscous materials. We compared concurrent manometric responses. Bolus head advance time, bolus presence time and bolus transit time were longer in the distal oesophagus during water and viscous swallows in the upright and supine positions. The total bolus head advance time and transit time, measured across the entire oesophageal body, were shorter for water than viscous swallows. The amplitudes of peristaltic pressure waves were lower for viscous swallows, and varied as a function of region. These studies demonstrated true functional differences between the proximal and distal oesophagus using multichannel intraluminal impedance and that the viscosity of the bolus is a determinant of oesophageal function.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalNeurogastroenterology and Motility
Issue number1
StatePublished - Feb 1 2004


  • Deglutition
  • Motility
  • Oesophagus
  • Peristalsis
  • Swallowing

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology


Dive into the research topics of 'Regional differences in oesophageal motor function'. Together they form a unique fingerprint.

Cite this