Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration

R. J. Mathew, W. H. Wilson, N. Y. Chiu, T. G. Turkington, T. R. Degrado, R. E. Coleman

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


Objective: The aim of this study was to examine the relationship between depersonalization induced by tetrahydrocannabinol (THC), and regional brain activation. Method: Cerebral blood flow (CBF) was measured by means of positron emission tomography (PET) in 59 normal right-handed volunteers before and following intravenous infusions of THC. Results: After THC, CBF showed a global increase which was more marked in the right hemisphere, frontal lobes and anterior cingulate. Conclusion: Regression analyses showed positive correlations between the right frontal and anterior cingulate and depersonalization.

Original languageEnglish (US)
Pages (from-to)67-75
Number of pages9
JournalActa Psychiatrica Scandinavica
Issue number1
StatePublished - 1999


  • Cerebral blood flow (CBF)
  • Depersonalization
  • Positron emission tomography (PET)
  • Tetrahydrocannabinol (THC)

ASJC Scopus subject areas

  • Psychiatry and Mental health


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