Regenerative medicine and tissue engineering in orthopaedic surgery

Alan Ivkovic, Inga Marijanovic, Damir Hudetz, Ryan M. Porter, Marko Pecina, Christopher H. Evans

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Orthopedic surgery is going through a serious paradigm shift; instead of simply replacing damaged tissues with prosthetic or allograft material, the aim is to regenerate them. This endeavor has generated the field of regenerative orthopaedics, an increasingly expanding area of research with hopes of providing new and better treatments for diseases and injuries affecting the musculoskeletal system. As part of this process, we are witnessing a substantial accumulation of new cellular and molecular insights into connective tissue function, coupled with emerging new concepts in stem cell biology and scaffolding technologies. Indeed, any successful strategy to regenerate musculoskeletal tissues can be portrayed as an intricate interplay between the three main constituents of the regenerative system: cells, environment and scaffolds. This review is not meant to be exhaustive and comprehensive, but aims to highlight concepts and key advances in the field of regenerative orthopaedics and tissue engineering, as well as to present current possibilities for clinical translation.

Original languageEnglish (US)
Pages (from-to)923-944
Number of pages22
JournalFrontiers in Bioscience - Elite
Volume3 E
Issue number3
StatePublished - Jan 6 2011


  • Bone
  • Cartilage
  • Mesenchymal stem cells
  • Orthopedic surgery
  • Regenerative medicine
  • Review
  • Scaffolds
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


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