A 43-year-old woman developed life-threatening refractory thrombocytopenia following autologous peripheral blood stem cell transplantation for metastatic breast carcinoma. Anti-PLA1 antibodies were demonstrated in the patient's plasma. Treatment with intravenous immunogiobulin and transfusion of PLA1-negative blood products restored platelet responsiveness. PLA1 alloantibodies should be considered as a possible cause of severe refractory thrombocytopenia in marrow transplant patients. It is important to make this diagnosis as the mainstay of treatment is the avoidance of blood products from PLA1-positive donors (98% of the population).
|Original language||English (US)|
|Number of pages||3|
|Journal||Bone Marrow Transplantation|
|State||Published - Jan 1 1996|
- Anti-PL antibodies
- Peripheral blood stem cells
ASJC Scopus subject areas