Reduction of noise-induced hearing loss using L-NAC and salicylate in the chinchilla

Richard D. Kopke, Peter A. Weisskopf, John L. Boone, Ronald L. Jackson, Derin C. Wester, Michael E. Hoffer, David C. Lambert, Christopher C. Charon, D. L. Ding, Dennis McBride

Research output: Contribution to journalArticlepeer-review

160 Scopus citations


The effects of a combination of two antioxidant compounds were studied in a chinchilla model of noise-induced hearing loss. After obtaining baseline hearing thresholds using inferior colliculus evoked potentials, chinchillas were exposed for 6 h to octave band noise centered at 4 kHz (105 dB SPL). Post-noise thresholds were obtained 1 h after the noise exposure, and then animals received either saline or salicylate and N-L-acetylcysteine combination. Another group received antioxidant treatment 1 h prior to noise. Hearing was tested at 1, 2 and 3 weeks post-noise. Subsequently, the cochleae were harvested, and cytocochleograms were prepared. There was a 20-40 dB SPL threshold shift at 3 weeks for tested controls. Permanent threshold shifts (PTS) were significantly reduced (P<0.05) to approximately 10 dB for the pre-treatment group at week 3. The PTS for the post-treatment group at week 3 was similar to the pre-treatment group at 1 and 2 kHz (0-10 dB) but was intermediate between the control and pre-treatment groups at 4 and 8 kHz (23 dB). Animals pre-treated with antioxidant had a significant reduction in hair cell loss but those post-treated with antioxidant had no protection from hair cell loss. These findings demonstrate the feasibility of reduction of noise-induced hearing loss using clinically available antioxidant compounds. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)138-146
Number of pages9
JournalHearing Research
Issue number1-2
StatePublished - 2000


  • Antioxidant
  • Chinchilla
  • Evoked potential
  • Hair cell
  • Loud noise

ASJC Scopus subject areas

  • Sensory Systems


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