Reducing PICU central line - Associated bloodstream infections: 3-Year results

Marlene R. Miller, Matthew F. Niedner, W. Charles Huskins, Elizabeth Colantuoni, Gayane Yenokyan, Michele Moss, Tom B. Rice, Debra Ridling, Deborah Campbell, Richard J. Brilli

Research output: Contribution to journalArticlepeer-review

124 Scopus citations


OBJECTIVES: To evaluate the long-term impact of pediatric central line care practices in reducing PICU central line - associated bloodstream infection (CLA-BSI) rates and to evaluate the added impact of chlorhexidine scrub and chlorhexidine-impregnated sponges. METHODS: A 3-year, multi-institutional, interrupted time-series design (October 2006 to September 2009), with historical control data, was used. A nested, 18-month, nonrandomized, factorial design was used to evaluate 2 additional interventions. Twenty-nine PICUs were included. Two central line care bundles (insertion and maintenance bundles) and 2 additional interventions (chlorhexidine scrub and chlorhexidine-impregnated sponges) were used. CLA-BSI rates (January 2004 to September 2009), insertion and maintenance bundle compliance rates (October 2006 to September 2009), and chlorhexidine scrub and chlorhexidine-impregnated sponge compliance rates (January 2008 to June 2009) were assessed. RESULTS: The average aggregate baseline PICU CLA-BSI rate decreased 56% over 36 months from 5.2 CLA-BSIs per 1000 line-days (95% confidence interval [CI]: 4.4-6.2 CLA-BSIs per 1000 line-days) to 2.3 CLA-BSIs per 1000 line-days (95% CI: 1.9-2.9 CLA-BSIs per 1000 linedays) (rate ratio: 0.44 [95% CI: 0.37-0.53]; P < .0001). No statistically significant differences in CLA-BSI rate decreases between PICUs using or not using either of the 2 additional interventions were found. CONCLUSIONS: Focused attention on consistent adherence to the use of pediatrics-specific central line insertion and maintenance bundles produced sustained, continually decreasing PICU CLA-BSI rates. Additional use of either chlorhexidine for central line entry scrub or chlorhexidine-impregnated sponges did not produce any statistically significant additional reduction in PICU CLA-BSI rates.

Original languageEnglish (US)
Pages (from-to)e1077-e1083
Issue number5
StatePublished - Nov 2011


  • Bloodstream infections
  • Children
  • Nosocomial infections
  • Pediatric intensive care unit

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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