TY - JOUR
T1 - Reduced Purkinje cell density in Huntington's disease
AU - Jeste, Dilip V.
AU - Barban, Lisa
AU - Parisi, Joseph
N1 - Funding Information:
Abbreviations: HD-Huntington’s disease. ’ We are most thankful to Dr. Vernon Annbrustmacher, Chief of Neuropathology, APIP, Dr. Richard Jed Wyatt, Chief of the Adult Psychiatry Branch, NIMH, Saint Elizabeths Hospital; Dr. Getano Molinari, Chief of Neurology, George Washington University Medical Center; and Mr. Mohamed Haleem, Curator, Yakovlev Collection, for their considerable help. The Yakovlev Collection is supported, in part, by NINCDS-AFIP Agreement YO 1-NS-7-0032-04. Please send reprint requests to Dr. Jeste, Intramural Research Program, NIMH, Saint Elizabeths Hospital, Washington, DC. 20032.
PY - 1984/7
Y1 - 1984/7
N2 - We studied, in a "blind" and quantitative fashion, the density of cerebellar Purkinje cells in 17 adult cases of Huntington's disease (HD), 17 patients with other movement disorders, 17 with schizophrenia, and 23 normal controls. There was a highly significant reduction in Purkinje cell density in HD compared with any of the other three groups. A much smaller difference in neuronal density between patients with other movement disorders and normal controls was barely significant. Eight of the 17 HD patients and only 1 of the other 57 subjects had Purjinje cell density less than 50% of the mean for the normal controls. The low density of Purkinje cells in HD could not be attributed to aging, seizures, or cause of death, nor was it merely a part of a generalized brain atrophy. The loss of large Purkinje cells suggests that the neuronal loss in HD may not be restricted to small and medium-size neurons.
AB - We studied, in a "blind" and quantitative fashion, the density of cerebellar Purkinje cells in 17 adult cases of Huntington's disease (HD), 17 patients with other movement disorders, 17 with schizophrenia, and 23 normal controls. There was a highly significant reduction in Purkinje cell density in HD compared with any of the other three groups. A much smaller difference in neuronal density between patients with other movement disorders and normal controls was barely significant. Eight of the 17 HD patients and only 1 of the other 57 subjects had Purjinje cell density less than 50% of the mean for the normal controls. The low density of Purkinje cells in HD could not be attributed to aging, seizures, or cause of death, nor was it merely a part of a generalized brain atrophy. The loss of large Purkinje cells suggests that the neuronal loss in HD may not be restricted to small and medium-size neurons.
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U2 - 10.1016/0014-4886(84)90162-6
DO - 10.1016/0014-4886(84)90162-6
M3 - Article
C2 - 6203775
AN - SCOPUS:0021139033
SN - 0014-4886
VL - 85
SP - 78
EP - 86
JO - Experimental Neurology
JF - Experimental Neurology
IS - 1
ER -