Reduced hippocampal functional connectivity in Alzheimer disease

Greg Allen, Holly Barnard, Roderick McColl, Andrea L. Hester, Julie A. Fields, Myron F. Weiner, Wendy K. Ringe, Anne M. Lipton, Matthew Brooker, Elizabeth McDonald, Craig D. Rubin, C. Munro Cullum

Research output: Contribution to journalArticlepeer-review

225 Scopus citations


Objective: To determine if functional connectivity of the hippocampus is reduced in patients with Alzheimer disease. Design: Functional connectivity magnetic resonance imaging was used to investigate coherence in the magnetic resonance signal between the hippocampus and all other regions of the brain. Participants: Eight patients with probable Alzheimer disease and 8 healthy volunteers. Results: Control subjects showed hippocampal functional connectivity with diffuse cortical, subcortical, and cerebellar sites, while patients demonstrated markedly reduced functional connectivity, including an absence of connectivity with the frontal lobes. Conclusion: These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease.

Original languageEnglish (US)
Pages (from-to)1482-1487
Number of pages6
JournalArchives of neurology
Issue number10
StatePublished - Oct 2007

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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