Reduced creatine kinase release with statin use at the time of myocardial infarction

Kevin A. Bybee, Stephen L. Kopecky, Brent A. Williams, Joseph G. Murphy, R. Scott Wright

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background: Statin pre-treatment has been shown to reduce myocardial infarct size in animal models. We evaluated peak creatine kinase levels in humans based on concomitant or very early statin initiation following myocardial infarction. Methods: We identified 66 consecutive patients who received a statin within 24 h of admission to our coronary care unit for myocardial infarction. Each statin patient was matched with three patients who had not received statin therapy (n=198). Statin patients were subgrouped into those receiving statin therapy at the time of infarction (n=44) and those initiated on statin therapy within 24 h of infarction (n=22). Peak total creatine kinase concentrations were compared between groups. A linear regression model was developed to test for differences in peak creatine kinase after adjusting for differences between groups. Results: Patients receiving statin therapy within 24 h of admission had significantly smaller median peak creatine kinase concentrations compared to those not receiving a statin (416 IU/l [258, 992] vs. 699 IU/l [339, 1728]; p=0.020). Subgroup analysis revealed that the lower peak creatine kinase concentrations within the statin group were a result of lower creatine kinase concentrations in those patients on a statin at the time of myocardial infarction (399 IU/l [255, 869] vs. 678 IU/l [276, 1870]; p<0.05). This difference retained statistical significance after adjustment for differences between groups. Conclusion: Statin therapy at the time of myocardial infarction is associated with lower peak creatine kinase concentrations. This suggests that statins may exhibit protective effects in the setting of myocardial ischemia and/or infarction in humans.

Original languageEnglish (US)
Pages (from-to)461-466
Number of pages6
JournalInternational Journal of Cardiology
Issue number3
StatePublished - Sep 2004


  • Creatine kinase
  • HMG-CoA reductase inhibitors
  • Myocardial infarction
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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