Recurrent thrombotic thrombocytopenic purpura (TTP) as a complication of acute relapsing pancreatitis

Jayant A. Talwalkar, Frederick W. Ruymann, Paul Marcoux, Francis A. Farraye

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Pancreatitis is a known complication of thrombotic thrombocytopenic purpura (TTP) found in approximately 2% of cases. The development of TTP as a clinical sequelae of acute pancreatitis has also been reported, including one patient with chronic pancreatitis who developed TTP on two occasions following acute exacerbations of pancreatitis. We describe a case in which multiple distinct episodes of TTP have followed the clinical and laboratory demonstration of acute pancreatitis in the same patient. Supportive care of the patient's pancreatitis and plasmapheresis in each case resulted in clinical improvement and resolution of TTP. While the pathophysiologic mechanism explaining this association remains unclear, the recurrence of TTP associated with the "rechallenge" of relapsing episodes of pancreatitis in our patient suggests that a cause-and-effect relationship does exist.

Original languageEnglish (US)
Pages (from-to)1096-1099
Number of pages4
JournalDigestive diseases and sciences
Issue number5
StatePublished - 2002


  • Acute pancreatitis
  • Plasmapheresis
  • Renal failure
  • Thrombotic thrombocytopenic purpura

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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