Recognition of genetic syndromes in families with suspected hereditary colon cancer syndromes

There is an increasing number of genetic disorders that predispose to colorectal cancer. Although these syndromes probably account for <5% of colorectal cancers, clinical recognition of these disorders is essential to assure the best clinical recommendations. There are increased risks for second cancers - both GI and non-GI cancers - in the patients and their relatives. Diagnosis of a familial cancer predisposition syndrome guides clinical management including early detection and prevention of cancers in such families.