Recent advances in the imaging of frontotemporal dementia

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31 Scopus citations


Neuroimaging has played an important role in the characterization of the frontotemporal dementia (FTD) syndromes, demonstrating neurodegenerative signatures that can aid in the differentiation of FTD from other neurodegenerative disorders. Recent advances have been driven largely by the refinement of the clinical syndromes that underlie FTD, and by the discovery of new genetic and pathological features associated with FTD. Many new imaging techniques and modalities are also now available that allow the assessment of other aspects of brain structure and function, such as diffusion tensor imaging and resting-state functional MRI. Studies have used these recent techniques, as well as traditional volumetric MRI, to provide further insight into disease progression across the many clinical, genetic, and pathological variants of FTD. Importantly, neuroimaging signatures have been identified that will improve the clinician's ability to predict underlying genetic and pathological features, and hence ultimately improve patient diagnosis.

Original languageEnglish (US)
Pages (from-to)715-723
Number of pages9
JournalCurrent neurology and neuroscience reports
Issue number6
StatePublished - Dec 2012


  • Agrammatic
  • Apraxia of speech
  • Atrophy
  • Behavioral variant frontotemporal dementia
  • C9orf72 hexanucleotide repeat
  • Diffusion tensor imaging
  • Functional connectivity
  • Fused in sarcoma
  • Magnetic resonance imaging
  • Progranulin
  • Resting-state functional magnetic resonance imaging
  • Semantic dementia
  • Tau
  • Transactivation response element DNA binding protein of 43 kDa
  • White matter tracts

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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