Recent advances in experimental modeling of the assembly of tau filaments

Li Wen Ko; Michael DeTure; Naruhiko Sahara; Rifki Chihab; Irving E. Vega; Shu Hui Yen

doi:10.1016/j.bbadis.2004.09.004

Recent advances in experimental modeling of the assembly of tau filaments

Li Wen Ko, Michael DeTure, Naruhiko Sahara, Rifki Chihab, Irving E. Vega, Shu Hui Yen

Neuroscience

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Intracellular assembly of microtubule-associated protein tau into filamentous inclusions is central to Alzheimer's disease and related disorders collectively known as tauopathies. Although tau mutations, posttranslational modifications and degradations have been the focus of investigations, the mechanism of tau fibrillogenesis in vivo still remains elusive. Different strategies have been undertaken to generate animal and cellular models for tauopathies. Some are used to study the molecular events leading to the assembly and accumulation of tau filaments, and others to identify potential therapeutic agents that are capable of impeding tauopathy. This review highlights the latest developments in new models and how their utility improves our understanding of the sequence of events leading to human tauopathy.

Original language	English (US)
Pages (from-to)	125-139
Number of pages	15
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1739
Issue number	2
DOIs	https://doi.org/10.1016/j.bbadis.2004.09.004
State	Published - Jan 3 2005

Keywords

Cellular model
Conditional transfectant
Tau aggregation
Tauopathy

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

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10.1016/j.bbadis.2004.09.004

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title = "Recent advances in experimental modeling of the assembly of tau filaments",

abstract = "Intracellular assembly of microtubule-associated protein tau into filamentous inclusions is central to Alzheimer's disease and related disorders collectively known as tauopathies. Although tau mutations, posttranslational modifications and degradations have been the focus of investigations, the mechanism of tau fibrillogenesis in vivo still remains elusive. Different strategies have been undertaken to generate animal and cellular models for tauopathies. Some are used to study the molecular events leading to the assembly and accumulation of tau filaments, and others to identify potential therapeutic agents that are capable of impeding tauopathy. This review highlights the latest developments in new models and how their utility improves our understanding of the sequence of events leading to human tauopathy.",

keywords = "Cellular model, Conditional transfectant, Tau aggregation, Tauopathy",

author = "Ko, {Li Wen} and Michael DeTure and Naruhiko Sahara and Rifki Chihab and Vega, {Irving E.} and Yen, {Shu Hui}",

note = "Funding Information: Research from Yen's laboratory was supported by NIH grant AG17216 and Mayo Foundation. We thank Dr. W.L. Lin for ultrastructural analysis and Dr. P. Davies, Dr. V.M.Y. Lee and Dr. P. Heutink, respectively, for antibodies CP13, Tau46 and P301L.",

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AU - DeTure, Michael

AU - Sahara, Naruhiko

AU - Chihab, Rifki

AU - Vega, Irving E.

AU - Yen, Shu Hui

N1 - Funding Information: Research from Yen's laboratory was supported by NIH grant AG17216 and Mayo Foundation. We thank Dr. W.L. Lin for ultrastructural analysis and Dr. P. Davies, Dr. V.M.Y. Lee and Dr. P. Heutink, respectively, for antibodies CP13, Tau46 and P301L.

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N2 - Intracellular assembly of microtubule-associated protein tau into filamentous inclusions is central to Alzheimer's disease and related disorders collectively known as tauopathies. Although tau mutations, posttranslational modifications and degradations have been the focus of investigations, the mechanism of tau fibrillogenesis in vivo still remains elusive. Different strategies have been undertaken to generate animal and cellular models for tauopathies. Some are used to study the molecular events leading to the assembly and accumulation of tau filaments, and others to identify potential therapeutic agents that are capable of impeding tauopathy. This review highlights the latest developments in new models and how their utility improves our understanding of the sequence of events leading to human tauopathy.

AB - Intracellular assembly of microtubule-associated protein tau into filamentous inclusions is central to Alzheimer's disease and related disorders collectively known as tauopathies. Although tau mutations, posttranslational modifications and degradations have been the focus of investigations, the mechanism of tau fibrillogenesis in vivo still remains elusive. Different strategies have been undertaken to generate animal and cellular models for tauopathies. Some are used to study the molecular events leading to the assembly and accumulation of tau filaments, and others to identify potential therapeutic agents that are capable of impeding tauopathy. This review highlights the latest developments in new models and how their utility improves our understanding of the sequence of events leading to human tauopathy.

KW - Cellular model

KW - Conditional transfectant

KW - Tau aggregation

KW - Tauopathy

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Recent advances in experimental modeling of the assembly of tau filaments

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Keywords

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