Specific tumor-associated rearrangements involving the regions 11 p 13 and 11 p 15 have been extensively documented. However, cytogenetic definition of the breakpoints occurring at the boundaries of these two regions was not precise enough to correlate with the molecular data. Using probes corresponding to the genes coding for MYOD1, CTSD, LDHA, and RBTNI and to the anonymous sequence D11S776, we have reassessed the breakpoints of three hybrids (J1.10, BID7, and N YX3.1) and confirmed the localization or more precisely mapped these four genes and the anonymous DNA marker on different subregions of 11 pter→p13, including the smallest region of 11p15.5 duplicated in a patient with Beckwith-Wiedemann syndrome.
ASJC Scopus subject areas
- Cell Biology