Rates of lobar atrophy in asymptomatic MAPT mutation carriers

Qin Chen, Bradley F. Boeve, Matthew Senjem, Nirubol Tosakulwong, Timothy G. Lesnick, Danielle Brushaber, Christina Dheel, J. Fields, Leah Forsberg, Ralitza Gavrilova, D. Gearhart, Jonathan Graff-Radford, Neill R. Graff-Radford, Clifford R. Jack, David T. Jones, David S. Knopman, Walter K. Kremers, M. Lapid, Rosa Rademakers, Jeremy SyrjanenAdam L. Boxer, H. Rosen, Zbigniew K. Wszolek, K. Kantarci

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Introduction: The aim of this study was to investigate the rates of lobar atrophy in the asymptomatic microtubule-associated protein tau (MAPT) mutation carriers. Methods: MAPT mutation carriers (n = 14; 10 asymptomatic, 4 converters from asymptomatic to symptomatic) and noncarriers (n = 13) underwent structural magnetic resonance imaging and were followed annually with a median of 9.2 years. Longitudinal changes in lobar atrophy were analyzed using the tensor-based morphometry with symmetric normalization algorithm. Results: The rate of temporal lobe atrophy in asymptomatic MAPT mutation carriers was faster than that in noncarriers. Although the greatest rate of atrophy was observed in the temporal lobe in converters, they also had increased atrophy rates in the frontal and parietal lobes compared to noncarriers. Discussion: Accelerated decline in temporal lobe volume occurs in asymptomatic MAPT mutation carriers followed by the frontal and parietal lobe in those who have become symptomatic. The findings have implications for monitoring the progression of neurodegeneration during clinical trials in asymptomatic MAPT mutation carriers.

Original languageEnglish (US)
Pages (from-to)338-346
Number of pages9
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
StatePublished - 2019


  • Asymptomatic
  • Frontotemporal dementia
  • Longitudinal
  • MAPT
  • Magnetic resonance image

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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