Rare allergic reaction of the kidney: Sitagliptin-induced acute tubulointerstitial nephritis

Ali A. Alsaad; Sarah M. Dhannoon; Sally Ann L. Pantin; Ivan E. Porter

doi:10.1136/bcr-2016-216297

Rare allergic reaction of the kidney: Sitagliptin-induced acute tubulointerstitial nephritis

Ali A. Alsaad, Sarah M. Dhannoon, Sally Ann L. Pantin, Ivan E. Porter

Nephrology and Hypertension (Internal Med)

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A 56-year-old man with a history of diabetes mellitus type-2 and stage-2 chronic kidney disease secondary to diabetic nephropathy presented with an acute deterioration of kidney function. Non-invasive work-up failed to reveal the underlying aetiology for the acute kidney failure. Kidney biopsy revealed acute tubulointerstitial nephritis (ATIN) which was attributed to sitagliptin use. Only few case reports have shown this correlation. Our aim is to alert physicians and other providers of the potential effect of sitagliptin to cause ATIN with this biopsy-proven case.

Original language	English (US)
Article number	216297
Journal	BMJ case reports
Volume	2016
DOIs	https://doi.org/10.1136/bcr-2016-216297
State	Published - 2016

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Medicine(all)

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abstract = "A 56-year-old man with a history of diabetes mellitus type-2 and stage-2 chronic kidney disease secondary to diabetic nephropathy presented with an acute deterioration of kidney function. Non-invasive work-up failed to reveal the underlying aetiology for the acute kidney failure. Kidney biopsy revealed acute tubulointerstitial nephritis (ATIN) which was attributed to sitagliptin use. Only few case reports have shown this correlation. Our aim is to alert physicians and other providers of the potential effect of sitagliptin to cause ATIN with this biopsy-proven case.",

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Rare allergic reaction of the kidney: Sitagliptin-induced acute tubulointerstitial nephritis

Abstract

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