Abstract
Patients with AIDS and disseminated Mycobacterium avium complex (MAC) infection received rifampin (600 mg) plus ethambutol (25 mg/kg) plus ciprofloxacin (750 mg) or matching placebos daily for 8 weeks. Patients were monitored every 2 weeks clinically and by quantitating MAC colony-forming units (cfu) per milliliter of blood. Analysis of baseline characteristics revealed no significant differences between groups. After 8 weeks, MAC cfu had decreased by ⩾1 log/mL in 4 of 9 treated patients versus 0 of 10 placebo recipients while increasing by ⩾1 log/mL, in 1 and 7, respectively (P =.006). While the average combined clinical response score declined in both groups, it tended to decrease less in treated patients (P =.36). On the other hand, dose-limiting toxicity (primarily nausea and adverse drug interactions) occurred in 9 of 12 treatment versus 1 of 12 placebo patients (P =.005). Combined rifabutin-ethambutol-ciprofloxacin therapy for disseminated MAC infection had significant microbiologic efficacy with some evidence of clinical efficacy but was associated with drug intolerance.
Original language | English (US) |
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Pages (from-to) | 112-119 |
Number of pages | 8 |
Journal | Journal of Infectious Diseases |
Volume | 168 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1993 |
ASJC Scopus subject areas
- General Medicine